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Science at the Center - Research

Betty Soliven, M.D.

Professor of Neurology

Clinical Interests

1. Director, Electrodiagnostic Laboratory for Neuromuscular diseases (EMG Lab).

2. Neuromuscular clinic: inflammatory and non-inflammatory neuropathies, myasthenia, inflammatory myopathies, ALS

3. Co-directs ALS/Muscular Dystrophy Clinic

4. Other interests: autoimmune diseases affecting the CNS such as multiple sclerosis

Laboratory Research

1. Immune mechanisms and demyelinating diseases of the CNS and PNS.

2. Glial electrophysiology and biology: signal transduction mechanisms in glial cells; K+ channels as drug targets in demyelinating diseases.

3. Mouse physiology and phenotypic characterization in transgenics and knockouts with neuropathic features.

Recent Publications (comprehensive list):

Yu C, Takeda M, and Soliven B. 2000. Regulation of cell cycle proteins by TNF-? and TGF-? in cells of oligodendroglial lineage. J. Neuroimmunol., 108:2-10.

Nagano S, Takeda M, Ma L and Soliven B. Cytokine-induced apoptosis of Schwann cells: role of nitric oxide, ceramide and cAMP. J. Neurochem., 77:1486:1495

Salomon B, Rhee L, Montag A, Soliven B, Arcella J, Girvin A, Miller SD, Bluestone JA. Development of spontaneous autoimmune peripheral neuropathy in B7.2 deficient NOD mice. J. Exp. Med. (submitted).

Soliven B, Ma L, Bae H, Attali B, Sobko A, Iwase T. 2003. PDGF upregulates the delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors. Am J of Physiol (Cell Physiol) 284:C85-C93.

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